Critical Care Registered Nurse (CCRN) Practice Exam

What adverse effect is associated with carbamazepine (Tegretol)?

1. Hypoglycemia

2. Hepatitis

3. Hypertension

4. Thrombocytopenia

The correct answer is: Hepatitis

The association of carbamazepine (Tegretol) with hepatitis as an adverse effect warrants attention due to its potential to cause liver-related issues. Carbamazepine is known to affect hepatic function, leading to enzyme elevation and, in some cases, hepatitis, which can manifest as jaundice, elevated liver enzymes, and other signs of liver dysfunction. While carbamazepine might contribute to various side effects, such as bone marrow suppression leading to thrombocytopenia, the more significant concern regarding liver toxicity makes hepatitis a particularly vital aspect of monitoring for patients on this medication. Platelet levels are not typically noted as an initial consideration when discussing carbamazepine's risks in relation to liver function, making hepatitis a stronger association overall. In terms of other adverse effects, hypoglycemia and hypertension are not commonly linked with carbamazepine. Hypoglycemia is more frequently associated with medications that directly affect insulin secretion or sensitivity, while hypertension is not a known direct side effect of carbamazepine. Thrombocytopenia, although relevant, is less immediately alarming compared to potential hepatotoxicity, which emphasizes why hepatitis stands out in this context.